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microtubule assembly

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Microtubule/Tubulin (14) ADC Cytotoxin (1) Akt (1) Amyloid-β (1) Apoptosis (4) Autophagy (1) Bcr-Abl (1) CRISPR/Cas9 (1) Fungal (1) HIV Protease (1) Isotope-Labeled Compounds (1) mTOR (1) Parasite (3) SphK (1)
By Research Areas:	Cancer (14) Infection (4) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Microtubule/Tubulin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14934

Rosabulin STA 5312	Microtubule/Tubulin	Cancer
Rosabulin (STA 5312) is a potent and orally active *microtubule* inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity .

HY-15552

Podofilox

3 Publications Verification

Podophyllotoxin
Microtubule/Tubulin Cancer

Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

Podofilox 3 Publications Verification Podophyllotoxin	Microtubule/Tubulin	Cancer
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-101989

Tubulin polymerization-IN-24	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly .

HY-13760

Tasidotin hydrochloride ILX651	Microtubule/Tubulin	Cancer
Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics.

HY-119692

Curvulin

Microtubule/Tubulin Others

Curvulin is a phytotoxin . Curvularin inhibits microtubule assembly and inhibits iNOS expression.

Curvulin	Microtubule/Tubulin	Others
Curvulin is a phytotoxin . Curvularin inhibits *microtubule* assembly and inhibits iNOS expression.

HY-17435

4'-Demethylepipodophyllotoxin 2 Publications Verification 4'-O-demethylepipodophyllotoxin; 4'-DMEP	Microtubule/Tubulin	Cancer
4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.

HY-115364

Parbendazole 5+ Cited Publications SKF 29044	Microtubule/Tubulin Parasite	Infection
Parbendazole is a potent inhibitor of *microtubule* assembly, destabilizes tubulin, with an EC₅₀ of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-15552S

Podofilox-d6	Microtubule/Tubulin	Cancer
Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II[1][2].

HY-13520

Nocodazole Maximum Cited Publications 53 Publications Verification Oncodazole; R17934	Microtubule/Tubulin Bcr-Abl CRISPR/Cas9 Autophagy Apoptosis	Cancer
Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of *microtubule. Nocodazole binds to β-tubulin and disrupts microtubule* assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, and activates CRISPR/Cas9.

HY-115364S

Parbendazole-d3 SKF 2904-d₃	Isotope-Labeled Compounds Microtubule/Tubulin Parasite	Infection
Parbendazole-d₃ is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-P4808

PHF6	Amyloid-β	Neurological Disease
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .

HY-115364R

Parbendazole (Standard) SKF 29044 (Standard)	Microtubule/Tubulin Parasite	Infection
Parbendazole (Standard) is the analytical standard of Parbendazole. This product is intended for research and analytical applications. Parbendazole is a potent inhibitor of *microtubule* assembly, destabilizes tubulin, with an EC₅₀ of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-144793

Deac-SS-Biotin	Others	Cancer
Deac-SS-Biotin is a potent antitumor agent. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity .

HY-N6773

Cytochalasin A	HIV Protease Fungal	Infection
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-153384

EAPB 02303	Microtubule/Tubulin Apoptosis	Cancer
EAPB 02303 is a *microtubule*-disrupting agent and inhibitor. EAPB 02303 induces mitosis arrest and impairment of spindle assembly. Thus, EAPB 02303 induces apoptosis and exhibits antitumor activity. EAPB 02303 also exhibits a potent synergy with Paclitaxel (HY-B0015) at lower concentrations .

HY-162143

SKI-349	SphK Akt mTOR	Cancer
SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells .

HY-148870

Maytansinoid B	ADC Cytotoxin	Cancer
Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis .

HY-125374

Larotaxel XRP9881	Apoptosis	Cancer
Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel .

HY-106008

Avanbulin BAL27862	Microtubule/Tubulin	Cancer
Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC₅₀ of 1.4 μM. Avanbulin binds to tubulin with an apparent K_d value of 244 nM. Avanbulin can be used for the research of cancer and cell division .

HY-145827

KIF18A-IN-4	Microtubule/Tubulin	Cancer
KIF18A-IN-4 is a moderately potent ATP and *microtubule* (MT) noncompetitive KIF18A inhibitor (IC₅₀=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity .

PHF6	Amyloid-β	Neurological Disease
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15552

Podofilox 3 Publications Verification Podophyllotoxin	Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-17435

4'-Demethylepipodophyllotoxin 2 Publications Verification 4'-O-demethylepipodophyllotoxin; 4'-DMEP	Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.

HY-N6773

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

Cat. No.	Product Name	Chemical Structure

HY-15552S

Podofilox-d6

Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II[1][2].

Podofilox-d6
Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II[1][2].

HY-115364S

Parbendazole-d3
Parbendazole-d₃ is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

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microtubule assembly

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products